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aminolevulinic acid oral
aminolevulinic acid oral, glipizide. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid administering other phototoxic drugs with aminolevulinic acid oral for 24 hr during perioperative period.
aminolevulinic acid topical
glipizide increases toxicity of aminolevulinic acid topical by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration of photosensitizing drugs may enhance the phototoxic reaction to photodynamic therapy with aminolevulinic acid.
ethanol
ethanol, glipizide. Other (see comment). Contraindicated. Comment: Excessive EtOH consumption may alter glycemic control. Some sulfonylureas may produce a disulfiram like rxn.
ivosidenib
ivosidenib will decrease the level or effect of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP2C9 substrates with ivosidenib or replace with alternate therapies. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs.
lumacaftor/ivacaftor
lumacaftor/ivacaftor will decrease the level or effect of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. Avoid or Use Alternate Drug. Sulfonylureas are CYP2C9 substrates. Lumacaftor/ivacaftor has the potential to induce CYP2C9.
methyl aminolevulinate
glipizide, methyl aminolevulinate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Each drug may increase the photosensitizing effect of the other.

Monitor Closely (161)

aceclofenac
aceclofenac increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
acemetacin
acemetacin increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
albiglutide
albiglutide, glipizide. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Serious hypoglycemia may occur when insulin secretagogues and GLP-1 agonists are concurrently administered. Consider lowering the dose of insulin secretagogue to reduce the risk of hypoglycemia. .
alogliptin
alogliptin, glipizide. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of alogliptin with insulin and/or insulin secretagogues (eg, sulfonylureas, meglitinide derivatives) may increase risk for hypoglycemia; may require lower dose of insulin or insulin secretagogue .
alpelisib
alpelisib will decrease the level or effect of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. Modify Therapy/Monitor Closely.
aluminum hydroxide
aluminum hydroxide will increase the level or effect of glipizide by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.
apalutamide
apalutamide will decrease the level or effect of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Coadministration of apalutamide, a weak CYP2C9 inducer, with drugs that are CYP2C9 substrates can result in lower exposure to these medications. Evaluate for loss of therapeutic effect if medication must be coadministered.
aripiprazole
aripiprazole, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
asenapine
asenapine, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
aspirin
aspirin increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
aspirin rectal
aspirin rectal increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
aspirin/citric acid/sodium bicarbonate
aspirin/citric acid/sodium bicarbonate increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
atazanavir
atazanavir decreases effects of glipizide by Other (see comment). Use Caution/Monitor. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. .
benazepril
benazepril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Additive hypogylcemic effects.
bexarotene
bexarotene increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Based on the mechanism of action, bexarotene capsules may increase the action of insulin enhancing agents, resulting in hypoglycemia. Hypoglycemia has not been associated with bexarotene monotherapy.
bitter melon
bitter melon increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypoglycemia.
calcium carbonate
calcium carbonate will increase the level or effect of glipizide by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.
canagliflozin
glipizide, canagliflozin. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Consider a lower dose of insulin or insulin secretagogue to avoid hypoglycemia when coadministered with canagliflozin.
cannabidiol
cannabidiol will increase the level or effect of glipizide by decreasing metabolism. Modify Therapy/Monitor Closely. Cannabidiol may potentially inhibit CYP2C9 activity. Consider reducing the dose when concomitantly using CYP2C9 substrates.
captopril
captopril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Both drugs lower blood glucose. Monitor blood glucose.
celecoxib
celecoxib increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
choline magnesium trisalicylate
choline magnesium trisalicylate increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
cimetidine
cimetidine will increase the level or effect of glipizide by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.
cinnamon
cinnamon increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.
ciprofibrate
ciprofibrate increases effects of glipizide by plasma protein binding competition. Use Caution/Monitor. Hypoglycemia; increased risk in hypoalbuminemia.
ciprofloxacin
ciprofloxacin increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Hyper and hypoglycemia have been reported in patients treated concomitantly with quinolones and antidiabetic agents. Careful monitoring of blood glucose is recommended.
clarithromycin
clarithromycin increases levels of glipizide by plasma protein binding competition. Use Caution/Monitor. Risk of hypoglycemia.
clotrimazole
clotrimazole increases levels of glipizide by decreasing metabolism. Use Caution/Monitor.
clozapine
clozapine, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
colesevelam
colesevelam decreases levels of glipizide by drug binding in GI tract. Use Caution/Monitor. Concomitant administration decreases glipizide absorption; however, absorption is not reduced when glipizide is administered 4 hr before colesevelam.
cyclosporine
glipizide, cyclosporine. unknown mechanism. Use Caution/Monitor. Cyclosporine may decrease the effects of sulfonylureas. Sulfonylureas may increase the effects of cyclosporine.
dapagliflozin
glipizide, dapagliflozin. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Consider a lower dose of insulin or insulin secretagogue to avoid hypoglycemia when coadministered with dapagliflozin.
darunavir
darunavir, glipizide. Other (see comment). Use Caution/Monitor. Comment: Darunavir may increase or decrease levels of glipizide. Use alternatives if available. Reports of hyperglycemia due to insulin resistance with protease inhibitors. .
diclofenac
diclofenac increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
diflunisal
diflunisal increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
disopyramide
disopyramide increases effects of glipizide by unspecified interaction mechanism. Use Caution/Monitor. Risk of hypoglycemia.
dulaglutide
dulaglutide, glipizide. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
elvitegravir/cobicistat/emtricitabine/tenofovir DF
elvitegravir/cobicistat/emtricitabine/tenofovir DF decreases levels of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Elvitegravir is a moderate CYP2C9 inducer.
empagliflozin
empagliflozin, glipizide. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Consider a lower dose of insulin or insulin secretagogue to avoid hypoglycemia when coadministered with SGLT2 inhibitors.
enalapril
enalapril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor.
ertugliflozin
ertugliflozin, glipizide. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Consider a lower dose of insulin or insulin secretagogue to avoid hypoglycemia when coadministered with ertugliflozin.
esomeprazole
esomeprazole will increase the level or effect of glipizide by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.
etodolac
etodolac increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
exenatide injectable solution
exenatide injectable solution, glipizide. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of hypoglycemia when exenatide is used in combination with agents that induce hypoglycemia. Consider lowering dose of sulfonylureas to reduce risk of hypoglycemia. .
exenatide injectable suspension
exenatide injectable suspension, glipizide. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of hypoglycemia when exenatide is used in combination with agents that induce hypoglycemia. Consider lowering dose of sulfonylureas to reduce risk of hypoglycemia.
famotidine
famotidine will increase the level or effect of glipizide by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.
fenofibrate
fenofibrate increases effects of glipizide by plasma protein binding competition. Use Caution/Monitor. Hypoglycemia; increased risk in hypoalbuminemia.
fenofibrate micronized
fenofibrate micronized increases effects of glipizide by plasma protein binding competition. Use Caution/Monitor. Hypoglycemia; increased risk in hypoalbuminemia.
fenofibric acid
fenofibric acid increases effects of glipizide by plasma protein binding competition. Use Caution/Monitor. Hypoglycemia; increased risk in hypoalbuminemia.
fenoprofen
fenoprofen increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
fleroxacin
fleroxacin increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely.
fluconazole
fluconazole increases levels of glipizide by decreasing metabolism. Use Caution/Monitor.
fluoxetine
fluoxetine increases effects of glipizide by unspecified interaction mechanism. Use Caution/Monitor. Risk of hypoglycemia.
flurbiprofen
flurbiprofen increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
fosamprenavir
fosamprenavir, glipizide. Other (see comment). Use Caution/Monitor. Comment: Fosamprenavir may increase or decrease levels of glipizide. Use alternatives if available. Reports of hyperglycemia due to insulin resistance with protease inhibitors. .
fosinopril
fosinopril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor.
gemfibrozil
gemfibrozil increases effects of glipizide by plasma protein binding competition. Use Caution/Monitor. Hypoglycemia; increased risk in hypoalbuminemia.
gemifloxacin
gemifloxacin increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely.
ibuprofen
ibuprofen increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
ibuprofen IV
ibuprofen IV increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
ibuprofen/famotidine
ibuprofen/famotidine will increase the level or effect of glipizide by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.
iloperidone
iloperidone, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
imidapril
imidapril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor.
indinavir
indinavir decreases effects of glipizide by Other (see comment). Use Caution/Monitor. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. .
indomethacin
indomethacin increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
insulin aspart
glipizide, insulin aspart. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin aspart protamine/insulin aspart
glipizide, insulin aspart protamine/insulin aspart. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin degludec
glipizide, insulin degludec. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin degludec/insulin aspart
glipizide, insulin degludec/insulin aspart. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin detemir
glipizide, insulin detemir. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin glargine
glipizide, insulin glargine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin glulisine
glipizide, insulin glulisine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin inhaled
glipizide, insulin inhaled. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin isophane human/insulin regular human
glipizide, insulin isophane human/insulin regular human. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin lispro
glipizide, insulin lispro. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin lispro protamine/insulin lispro
glipizide, insulin lispro protamine/insulin lispro. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin NPH
glipizide, insulin NPH. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin regular human
glipizide, insulin regular human. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
isocarboxazid
isocarboxazid increases effects of glipizide by unknown mechanism. Use Caution/Monitor.
ketoconazole
ketoconazole increases levels of glipizide by decreasing metabolism. Use Caution/Monitor.
ketoprofen
ketoprofen increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
ketorolac
ketorolac increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
ketorolac intranasal
ketorolac intranasal increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
ketotifen, ophthalmic
ketotifen, ophthalmic, glipizide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
levofloxacin
levofloxacin increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely.
linagliptin
glipizide, linagliptin. Other (see comment). Use Caution/Monitor. Comment: When linagliptin is used in combination with sulfonylureas, a lower dose of the sulfonylurea may be required to reduce risk of hypoglycemia.
linezolid
linezolid increases effects of glipizide by unknown mechanism. Use Caution/Monitor.
liraglutide
liraglutide, glipizide. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Serious hypoglycemia may occur when insulin secretagogues and GLP-1 agonists are concurrently administered. Consider lowering the dose of insulin secretagogue to reduce the risk of hypoglycemia. .
lisinopril
lisinopril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor.
lixisenatide
lixisenatide, glipizide. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Risk of hypoglycemia increased when coadministered with sulfonylureas. Sulfonylurea dosage reduction may be required.
lopinavir
lopinavir, glipizide. Other (see comment). Use Caution/Monitor. Comment: Lopinavir may increase or decrease levels of glipizide. Reports of hyperglycemia due to insulin resistance with protease inhibitors. .
lornoxicam
lornoxicam increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
lurasidone
lurasidone, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
marijuana
marijuana decreases effects of glipizide by pharmacodynamic antagonism. Use Caution/Monitor.
mecasermin
mecasermin increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Additive hypoglycemic effects.
meclofenamate
meclofenamate increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
mefenamic acid
mefenamic acid increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
meloxicam
meloxicam increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
metreleptin
glipizide, metreleptin. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of metreleptin with insulin and/or insulin secretagogues (eg, sulfonylureas, meglitinide derivatives) may increase risk for hypoglycemia; may require lower dose of insulin or insulin secretagogue.
miconazole vaginal
miconazole vaginal increases levels of glipizide by decreasing metabolism. Use Caution/Monitor.
mipomersen
mipomersen, glipizide. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Both drugs have potential to increase hepatic enzymes; monitor LFTs.
moexipril
moexipril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor.
moxifloxacin
moxifloxacin increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely.
nabumetone
nabumetone increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
nadolol
nadolol decreases effects of glipizide by pharmacodynamic antagonism. Use Caution/Monitor. Non selective beta blockers may also mask the symptoms of hypoglycemia.
naproxen
naproxen increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
nelfinavir
nelfinavir decreases effects of glipizide by Other (see comment). Use Caution/Monitor. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. .
nitazoxanide
nitazoxanide, glipizide. Either increases levels of the other by Mechanism: plasma protein binding competition. Use Caution/Monitor.
nitisinone
nitisinone will increase the level or effect of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Nitisinone inhibits CYP2C9. Caution if CYP2C9 substrate coadministered, particularly those with a narrow therapeutic index.
ofloxacin
ofloxacin increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely.
olanzapine
olanzapine, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
opuntia ficus indica
opuntia ficus indica increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor.
ospemifene
glipizide, ospemifene. Either increases levels of the other by plasma protein binding competition. Modify Therapy/Monitor Closely.
oxaprozin
oxaprozin increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
paliperidone
paliperidone, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
parecoxib
parecoxib increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
peginterferon alfa 2b
peginterferon alfa 2b decreases levels of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. When patients are administered peginterferon alpha-2b with CYP2C9 substrates, the therapeutic effect of these drugs may be altered. .
perindopril
perindopril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor.
phenelzine
phenelzine increases effects of glipizide by unknown mechanism. Use Caution/Monitor.
pindolol
pindolol decreases effects of glipizide by pharmacodynamic antagonism. Use Caution/Monitor. Non selective beta blockers may also mask the symptoms of hypoglycemia.
piroxicam
piroxicam increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
posaconazole
posaconazole increases levels of glipizide by decreasing metabolism. Use Caution/Monitor.
probenecid
probenecid increases levels of glipizide by unspecified interaction mechanism. Use Caution/Monitor. Risk of hypoglycemia.
propranolol
propranolol decreases effects of glipizide by pharmacodynamic antagonism. Use Caution/Monitor. Non selective beta blockers may also mask the symptoms of hypoglycemia.
quetiapine
quetiapine, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
quinapril
quinapril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor.
ramipril
ramipril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor.
rasagiline
rasagiline increases effects of glipizide by unknown mechanism. Use Caution/Monitor.
rifabutin
rifabutin decreases levels of glipizide by increasing metabolism. Use Caution/Monitor.
rifampin
rifampin decreases levels of glipizide by increasing metabolism. Use Caution/Monitor.
rifapentine
rifapentine decreases levels of glipizide by increasing metabolism. Use Caution/Monitor.
risperidone
risperidone, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
ritonavir
ritonavir, glipizide. Other (see comment). Use Caution/Monitor. Comment: Ritonavir may increase or decrease levels of glipizide. Reports of hyperglycemia due to insulin resistance with protease inhibitors. .
rucaparib
rucaparib will increase the level or effect of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. Modify Therapy/Monitor Closely. Adjust dosage of CYP2C9 substrates, if clinically indicated.
salicylates (non-asa)
salicylates (non-asa) increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
salsalate
salsalate increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
saquinavir
saquinavir decreases effects of glipizide by Other (see comment). Use Caution/Monitor. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. .
selegiline
selegiline increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Serum glucose should be monitored closely when MAOIs are added to any regimen containing antidiabetic medications. Hypoglycemic effects may be increased.
selegiline transdermal
selegiline transdermal increases effects of glipizide by unknown mechanism. Use Caution/Monitor.
semaglutide
semaglutide, glipizide. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of insulin secretagogues with GLP-1 agonists may increase hypoglycemia risk. Lowering the insulin secretagogue dose may reduce hypoglycemia risk. .
shark cartilage
shark cartilage increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
sodium bicarbonate
sodium bicarbonate will increase the level or effect of glipizide by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.
sodium citrate/citric acid
sodium citrate/citric acid will increase the level or effect of glipizide by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.
somapacitan
somapacitan decreases effects of glipizide by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Growth hormone products may decrease insulin sensitivity, particularly at higher doses. Antidiabetic agents may require dose adjustment after initiating somapacitan. .
sulfadiazine
sulfadiazine increases levels of glipizide by plasma protein binding competition. Use Caution/Monitor.
sulfamethoxazole
sulfamethoxazole increases levels of glipizide by plasma protein binding competition. Use Caution/Monitor.
sulfamethoxypyridazine
sulfamethoxypyridazine increases effects of glipizide by unspecified interaction mechanism. Use Caution/Monitor. Risk of hypoglycemia.
sulfasalazine
sulfasalazine increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
sulfisoxazole
sulfisoxazole increases levels of glipizide by plasma protein binding competition. Use Caution/Monitor.
sulindac
sulindac increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
timolol
timolol decreases effects of glipizide by pharmacodynamic antagonism. Use Caution/Monitor. Non selective beta blockers may also mask the symptoms of hypoglycemia.
tipranavir
tipranavir decreases effects of glipizide by Other (see comment). Use Caution/Monitor. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. .
tolfenamic acid
tolfenamic acid increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
tolmetin
tolmetin increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
trandolapril
trandolapril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor.
tranylcypromine
tranylcypromine increases effects of glipizide by unknown mechanism. Use Caution/Monitor.
triamcinolone acetonide injectable suspension
triamcinolone acetonide injectable suspension decreases effects of glipizide by pharmacodynamic antagonism. Use Caution/Monitor. Corticosteroids may diminish hypoglycemic effect of antidiabetic agents. Monitor blood glucose levels carefully.
trimagnesium citrate anhydrous
trimagnesium citrate anhydrous increases levels of glipizide by enhancing GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
voriconazole
voriconazole increases levels of glipizide by decreasing metabolism. Use Caution/Monitor.
xipamide
xipamide decreases levels of glipizide by increasing renal clearance. Use Caution/Monitor.
ziprasidone
ziprasidone, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.

Minor (85)

agrimony
agrimony increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
American ginseng
American ginseng increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
amitriptyline
amitriptyline increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
amoxapine
amoxapine increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
anamu
anamu increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Theoretical interaction.
aspirin
aspirin increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
aspirin rectal
aspirin rectal increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
aspirin/citric acid/sodium bicarbonate
aspirin/citric acid/sodium bicarbonate increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
balsalazide
balsalazide increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
bendroflumethiazide
bendroflumethiazide decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose.
budesonide
budesonide decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown.
chloramphenicol
chloramphenicol increases levels of glipizide by decreasing metabolism. Minor/Significance Unknown.
chlorothiazide
chlorothiazide decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose.
chlorthalidone
chlorthalidone decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose.
choline magnesium trisalicylate
choline magnesium trisalicylate increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
chromium
chromium increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
clomipramine
clomipramine increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
clonidine
clonidine decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Diminished symptoms of hypoglycemia.clonidine, glipizide. Other (see comment). Minor/Significance Unknown. Comment: Decreased symptoms of hypoglycemia. Mechanism: decreased hypoglycemia induced catecholamine production.
cornsilk
cornsilk increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of hypoglycemia (theoretical interaction).
cortisone
cortisone decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown.
cyclopenthiazide
cyclopenthiazide decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose.
damiana
damiana decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction.
danazol
danazol increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
deflazacort
deflazacort decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown.
desipramine
desipramine increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
devil's claw
devil's claw increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
dexamethasone
dexamethasone decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown.
diflunisal
diflunisal increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
doxepin
doxepin increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
elderberry
elderberry increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of hypoglycemia (in vitro research).
eucalyptus
eucalyptus increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Theoretical interaction.
fludrocortisone
fludrocortisone decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown.
fluoxymesterone
fluoxymesterone increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
fo-ti
fo-ti increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
forskolin
forskolin increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Colenol, a compound found in Coleus root, may stimulate insulin release.
gotu kola
gotu kola increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
guanfacine
guanfacine decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Diminished symptoms of hypoglycemia.guanfacine, glipizide. Other (see comment). Minor/Significance Unknown. Comment: Decreased symptoms of hypoglycemia. Mechanism: decreased hypoglycemia induced catecholamine production.
gymnema
gymnema increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
horse chestnut seed
horse chestnut seed increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
hydrochlorothiazide
hydrochlorothiazide decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose.
hydrocortisone
hydrocortisone decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown.
imipramine
imipramine increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
indapamide
indapamide decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose.
isoniazid
isoniazid decreases effects of glipizide by unspecified interaction mechanism. Minor/Significance Unknown.
juniper
juniper increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of hypoglycemia (theoretical interaction).
lofepramine
lofepramine increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
lycopus
lycopus increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of hypoglycemia (theoretical interaction).
maitake
maitake increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of hypoglycemia (animal research).
maprotiline
maprotiline increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
mesalamine
mesalamine increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
mesterolone
mesterolone increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
methyclothiazide
methyclothiazide decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose.
methylprednisolone
methylprednisolone decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown.
methyltestosterone
methyltestosterone increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
metolazone
metolazone decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose.
nettle
nettle increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
nizatidine
nizatidine will increase the level or effect of glipizide by increasing gastric pH. Applies only to oral form of both agents. Minor/Significance Unknown.
nortriptyline
nortriptyline increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
ofloxacin
ofloxacin, glipizide. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Potential dysglycemia.
omeprazole
omeprazole will increase the level or effect of glipizide by affecting hepatic enzyme CYP2C19 metabolism. Minor/Significance Unknown.
orlistat
orlistat increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
oxandrolone
oxandrolone increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
oxymetholone
oxymetholone increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
pegvisomant
pegvisomant increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
potassium acid phosphate
potassium acid phosphate increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.
potassium chloride
potassium chloride increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.
potassium citrate
potassium citrate increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.
prednisolone
prednisolone decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown.
prednisone
prednisone decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown.
protriptyline
protriptyline increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
sage
sage increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
salicylates (non-asa)
salicylates (non-asa) increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
salsalate
salsalate increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
sitagliptin
sitagliptin, glipizide. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Risk of hypoglycemia with combination is unknown.
stevia
stevia increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
sulfasalazine
sulfasalazine increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
tacrolimus
glipizide increases levels of tacrolimus by unknown mechanism. Minor/Significance Unknown.
testosterone
testosterone increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
testosterone buccal system
testosterone buccal system increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
testosterone topical
testosterone topical increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
tongkat ali
tongkat ali increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Risk of hypoglycemia.
trazodone
trazodone increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
trimipramine
trimipramine increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
vanadium
vanadium increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
willow bark
willow bark increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.

aceclofenac
Monitor Closely (1)aceclofenac increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
acemetacin
Monitor Closely (1)acemetacin increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
agrimony
Minor (1)agrimony increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
albiglutide
Monitor Closely (1)albiglutide, glipizide. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Serious hypoglycemia may occur when insulin secretagogues and GLP-1 agonists are concurrently administered. Consider lowering the dose of insulin secretagogue to reduce the risk of hypoglycemia. .
alogliptin
Monitor Closely (1)alogliptin, glipizide. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of alogliptin with insulin and/or insulin secretagogues (eg, sulfonylureas, meglitinide derivatives) may increase risk for hypoglycemia; may require lower dose of insulin or insulin secretagogue .
alpelisib
Monitor Closely (1)alpelisib will decrease the level or effect of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. Modify Therapy/Monitor Closely.
aluminum hydroxide
Monitor Closely (1)aluminum hydroxide will increase the level or effect of glipizide by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.
American ginseng
Minor (1)American ginseng increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
aminolevulinic acid oral
Serious - Use Alternative (1)aminolevulinic acid oral, glipizide. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid administering other phototoxic drugs with aminolevulinic acid oral for 24 hr during perioperative period.
aminolevulinic acid topical
Serious - Use Alternative (1)glipizide increases toxicity of aminolevulinic acid topical by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration of photosensitizing drugs may enhance the phototoxic reaction to photodynamic therapy with aminolevulinic acid.
amitriptyline
Minor (1)amitriptyline increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
amoxapine
Minor (1)amoxapine increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
anamu
Minor (1)anamu increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Theoretical interaction.
apalutamide
Monitor Closely (1)apalutamide will decrease the level or effect of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Coadministration of apalutamide, a weak CYP2C9 inducer, with drugs that are CYP2C9 substrates can result in lower exposure to these medications. Evaluate for loss of therapeutic effect if medication must be coadministered.
aripiprazole
Monitor Closely (1)aripiprazole, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
asenapine
Monitor Closely (1)asenapine, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
aspirin
Monitor Closely (1)aspirin increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.Minor (1)aspirin increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
aspirin rectal
Monitor Closely (1)aspirin rectal increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.Minor (1)aspirin rectal increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
aspirin/citric acid/sodium bicarbonate
Monitor Closely (1)aspirin/citric acid/sodium bicarbonate increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.Minor (1)aspirin/citric acid/sodium bicarbonate increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
atazanavir
Monitor Closely (1)atazanavir decreases effects of glipizide by Other (see comment). Use Caution/Monitor. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. .
balsalazide
Minor (1)balsalazide increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
benazepril
Monitor Closely (1)benazepril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Additive hypogylcemic effects.
bendroflumethiazide
Minor (1)bendroflumethiazide decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose.
bexarotene
Monitor Closely (1)bexarotene increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Based on the mechanism of action, bexarotene capsules may increase the action of insulin enhancing agents, resulting in hypoglycemia. Hypoglycemia has not been associated with bexarotene monotherapy.
bitter melon
Monitor Closely (1)bitter melon increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypoglycemia.
budesonide
Minor (1)budesonide decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown.
calcium carbonate
Monitor Closely (1)calcium carbonate will increase the level or effect of glipizide by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.
canagliflozin
Monitor Closely (1)glipizide, canagliflozin. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Consider a lower dose of insulin or insulin secretagogue to avoid hypoglycemia when coadministered with canagliflozin.
cannabidiol
Monitor Closely (1)cannabidiol will increase the level or effect of glipizide by decreasing metabolism. Modify Therapy/Monitor Closely. Cannabidiol may potentially inhibit CYP2C9 activity. Consider reducing the dose when concomitantly using CYP2C9 substrates.
captopril
Monitor Closely (1)captopril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Both drugs lower blood glucose. Monitor blood glucose.
celecoxib
Monitor Closely (1)celecoxib increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
chloramphenicol
Minor (1)chloramphenicol increases levels of glipizide by decreasing metabolism. Minor/Significance Unknown.
chlorothiazide
Minor (1)chlorothiazide decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose.
chlorthalidone
Minor (1)chlorthalidone decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose.
choline magnesium trisalicylate
Monitor Closely (1)choline magnesium trisalicylate increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.Minor (1)choline magnesium trisalicylate increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
chromium
Minor (1)chromium increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
cimetidine
Monitor Closely (1)cimetidine will increase the level or effect of glipizide by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.
cinnamon
Monitor Closely (1)cinnamon increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Potential for hypoglycemia.
ciprofibrate
Monitor Closely (1)ciprofibrate increases effects of glipizide by plasma protein binding competition. Use Caution/Monitor. Hypoglycemia; increased risk in hypoalbuminemia.
ciprofloxacin
Monitor Closely (1)ciprofloxacin increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Hyper and hypoglycemia have been reported in patients treated concomitantly with quinolones and antidiabetic agents. Careful monitoring of blood glucose is recommended.
clarithromycin
Monitor Closely (1)clarithromycin increases levels of glipizide by plasma protein binding competition. Use Caution/Monitor. Risk of hypoglycemia.
clomipramine
Minor (1)clomipramine increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
clonidine

Minor (2)clonidine decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Diminished symptoms of hypoglycemia.

clonidine, glipizide. Other (see comment). Minor/Significance Unknown. Comment: Decreased symptoms of hypoglycemia. Mechanism: decreased hypoglycemia induced catecholamine production.
clotrimazole
Monitor Closely (1)clotrimazole increases levels of glipizide by decreasing metabolism. Use Caution/Monitor.
clozapine
Monitor Closely (1)clozapine, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
colesevelam
Monitor Closely (1)colesevelam decreases levels of glipizide by drug binding in GI tract. Use Caution/Monitor. Concomitant administration decreases glipizide absorption; however, absorption is not reduced when glipizide is administered 4 hr before colesevelam.
cornsilk
Minor (1)cornsilk increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of hypoglycemia (theoretical interaction).
cortisone
Minor (1)cortisone decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown.
cyclopenthiazide
Minor (1)cyclopenthiazide decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose.
cyclosporine
Monitor Closely (1)glipizide, cyclosporine. unknown mechanism. Use Caution/Monitor. Cyclosporine may decrease the effects of sulfonylureas. Sulfonylureas may increase the effects of cyclosporine.
damiana
Minor (1)damiana decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction.
danazol
Minor (1)danazol increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
dapagliflozin
Monitor Closely (1)glipizide, dapagliflozin. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Consider a lower dose of insulin or insulin secretagogue to avoid hypoglycemia when coadministered with dapagliflozin.
darunavir
Monitor Closely (1)darunavir, glipizide. Other (see comment). Use Caution/Monitor. Comment: Darunavir may increase or decrease levels of glipizide. Use alternatives if available. Reports of hyperglycemia due to insulin resistance with protease inhibitors. .
deflazacort
Minor (1)deflazacort decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown.
desipramine
Minor (1)desipramine increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
devil's claw
Minor (1)devil's claw increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
dexamethasone
Minor (1)dexamethasone decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown.
diclofenac
Monitor Closely (1)diclofenac increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
diflunisal
Monitor Closely (1)diflunisal increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.Minor (1)diflunisal increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
disopyramide
Monitor Closely (1)disopyramide increases effects of glipizide by unspecified interaction mechanism. Use Caution/Monitor. Risk of hypoglycemia.
doxepin
Minor (1)doxepin increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
dulaglutide
Monitor Closely (1)dulaglutide, glipizide. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
elderberry
Minor (1)elderberry increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of hypoglycemia (in vitro research).
elvitegravir/cobicistat/emtricitabine/tenofovir DF
Monitor Closely (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF decreases levels of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Elvitegravir is a moderate CYP2C9 inducer.
empagliflozin
Monitor Closely (1)empagliflozin, glipizide. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Consider a lower dose of insulin or insulin secretagogue to avoid hypoglycemia when coadministered with SGLT2 inhibitors.
enalapril
Monitor Closely (1)enalapril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor.
ertugliflozin
Monitor Closely (1)ertugliflozin, glipizide. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Consider a lower dose of insulin or insulin secretagogue to avoid hypoglycemia when coadministered with ertugliflozin.
esomeprazole
Monitor Closely (1)esomeprazole will increase the level or effect of glipizide by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.
ethanol
Serious - Use Alternative (1)ethanol, glipizide. Other (see comment). Contraindicated. Comment: Excessive EtOH consumption may alter glycemic control. Some sulfonylureas may produce a disulfiram like rxn.
etodolac
Monitor Closely (1)etodolac increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
eucalyptus
Minor (1)eucalyptus increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Theoretical interaction.
exenatide injectable solution
Monitor Closely (1)exenatide injectable solution, glipizide. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of hypoglycemia when exenatide is used in combination with agents that induce hypoglycemia. Consider lowering dose of sulfonylureas to reduce risk of hypoglycemia. .
exenatide injectable suspension
Monitor Closely (1)exenatide injectable suspension, glipizide. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of hypoglycemia when exenatide is used in combination with agents that induce hypoglycemia. Consider lowering dose of sulfonylureas to reduce risk of hypoglycemia.
famotidine
Monitor Closely (1)famotidine will increase the level or effect of glipizide by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.
fenofibrate
Monitor Closely (1)fenofibrate increases effects of glipizide by plasma protein binding competition. Use Caution/Monitor. Hypoglycemia; increased risk in hypoalbuminemia.
fenofibrate micronized
Monitor Closely (1)fenofibrate micronized increases effects of glipizide by plasma protein binding competition. Use Caution/Monitor. Hypoglycemia; increased risk in hypoalbuminemia.
fenofibric acid
Monitor Closely (1)fenofibric acid increases effects of glipizide by plasma protein binding competition. Use Caution/Monitor. Hypoglycemia; increased risk in hypoalbuminemia.
fenoprofen
Monitor Closely (1)fenoprofen increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
fleroxacin
Monitor Closely (1)fleroxacin increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely.
fluconazole
Monitor Closely (1)fluconazole increases levels of glipizide by decreasing metabolism. Use Caution/Monitor.
fludrocortisone
Minor (1)fludrocortisone decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown.
fluoxetine
Monitor Closely (1)fluoxetine increases effects of glipizide by unspecified interaction mechanism. Use Caution/Monitor. Risk of hypoglycemia.
fluoxymesterone
Minor (1)fluoxymesterone increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
flurbiprofen
Monitor Closely (1)flurbiprofen increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
fo-ti
Minor (1)fo-ti increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
forskolin
Minor (1)forskolin increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Colenol, a compound found in Coleus root, may stimulate insulin release.
fosamprenavir
Monitor Closely (1)fosamprenavir, glipizide. Other (see comment). Use Caution/Monitor. Comment: Fosamprenavir may increase or decrease levels of glipizide. Use alternatives if available. Reports of hyperglycemia due to insulin resistance with protease inhibitors. .
fosinopril
Monitor Closely (1)fosinopril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor.
gemfibrozil
Monitor Closely (1)gemfibrozil increases effects of glipizide by plasma protein binding competition. Use Caution/Monitor. Hypoglycemia; increased risk in hypoalbuminemia.
gemifloxacin
Monitor Closely (1)gemifloxacin increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely.
gotu kola
Minor (1)gotu kola increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
guanfacine

Minor (2)guanfacine decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Diminished symptoms of hypoglycemia.

guanfacine, glipizide. Other (see comment). Minor/Significance Unknown. Comment: Decreased symptoms of hypoglycemia. Mechanism: decreased hypoglycemia induced catecholamine production.
gymnema
Minor (1)gymnema increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
horse chestnut seed
Minor (1)horse chestnut seed increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
hydrochlorothiazide
Minor (1)hydrochlorothiazide decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose.
hydrocortisone
Minor (1)hydrocortisone decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown.
ibuprofen
Monitor Closely (1)ibuprofen increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
ibuprofen IV
Monitor Closely (1)ibuprofen IV increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
ibuprofen/famotidine
Monitor Closely (1)ibuprofen/famotidine will increase the level or effect of glipizide by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.
iloperidone
Monitor Closely (1)iloperidone, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
imidapril
Monitor Closely (1)imidapril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor.
imipramine
Minor (1)imipramine increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
indapamide
Minor (1)indapamide decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose.
indinavir
Monitor Closely (1)indinavir decreases effects of glipizide by Other (see comment). Use Caution/Monitor. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. .
indomethacin
Monitor Closely (1)indomethacin increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
insulin aspart
Monitor Closely (1)glipizide, insulin aspart. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin aspart protamine/insulin aspart
Monitor Closely (1)glipizide, insulin aspart protamine/insulin aspart. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin degludec
Monitor Closely (1)glipizide, insulin degludec. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin degludec/insulin aspart
Monitor Closely (1)glipizide, insulin degludec/insulin aspart. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin detemir
Monitor Closely (1)glipizide, insulin detemir. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin glargine
Monitor Closely (1)glipizide, insulin glargine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin glulisine
Monitor Closely (1)glipizide, insulin glulisine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin inhaled
Monitor Closely (1)glipizide, insulin inhaled. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin isophane human/insulin regular human
Monitor Closely (1)glipizide, insulin isophane human/insulin regular human. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin lispro
Monitor Closely (1)glipizide, insulin lispro. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin lispro protamine/insulin lispro
Monitor Closely (1)glipizide, insulin lispro protamine/insulin lispro. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin NPH
Monitor Closely (1)glipizide, insulin NPH. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
insulin regular human
Monitor Closely (1)glipizide, insulin regular human. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents.
isocarboxazid
Monitor Closely (1)isocarboxazid increases effects of glipizide by unknown mechanism. Use Caution/Monitor.
isoniazid
Minor (1)isoniazid decreases effects of glipizide by unspecified interaction mechanism. Minor/Significance Unknown.
ivosidenib
Serious - Use Alternative (1)ivosidenib will decrease the level or effect of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP2C9 substrates with ivosidenib or replace with alternate therapies. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs.
juniper
Minor (1)juniper increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of hypoglycemia (theoretical interaction).
ketoconazole
Monitor Closely (1)ketoconazole increases levels of glipizide by decreasing metabolism. Use Caution/Monitor.
ketoprofen
Monitor Closely (1)ketoprofen increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
ketorolac
Monitor Closely (1)ketorolac increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
ketorolac intranasal
Monitor Closely (1)ketorolac intranasal increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
ketotifen, ophthalmic
Monitor Closely (1)ketotifen, ophthalmic, glipizide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
levofloxacin
Monitor Closely (1)levofloxacin increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely.
linagliptin
Monitor Closely (1)glipizide, linagliptin. Other (see comment). Use Caution/Monitor. Comment: When linagliptin is used in combination with sulfonylureas, a lower dose of the sulfonylurea may be required to reduce risk of hypoglycemia.
linezolid
Monitor Closely (1)linezolid increases effects of glipizide by unknown mechanism. Use Caution/Monitor.
liraglutide
Monitor Closely (1)liraglutide, glipizide. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Serious hypoglycemia may occur when insulin secretagogues and GLP-1 agonists are concurrently administered. Consider lowering the dose of insulin secretagogue to reduce the risk of hypoglycemia. .
lisinopril
Monitor Closely (1)lisinopril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor.
lixisenatide
Monitor Closely (1)lixisenatide, glipizide. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Risk of hypoglycemia increased when coadministered with sulfonylureas. Sulfonylurea dosage reduction may be required.
lofepramine
Minor (1)lofepramine increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
lopinavir
Monitor Closely (1)lopinavir, glipizide. Other (see comment). Use Caution/Monitor. Comment: Lopinavir may increase or decrease levels of glipizide. Reports of hyperglycemia due to insulin resistance with protease inhibitors. .
lornoxicam
Monitor Closely (1)lornoxicam increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
lumacaftor/ivacaftor
Serious - Use Alternative (1)lumacaftor/ivacaftor will decrease the level or effect of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. Avoid or Use Alternate Drug. Sulfonylureas are CYP2C9 substrates. Lumacaftor/ivacaftor has the potential to induce CYP2C9.
lurasidone
Monitor Closely (1)lurasidone, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
lycopus
Minor (1)lycopus increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of hypoglycemia (theoretical interaction).
maitake
Minor (1)maitake increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of hypoglycemia (animal research).
maprotiline
Minor (1)maprotiline increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
marijuana
Monitor Closely (1)marijuana decreases effects of glipizide by pharmacodynamic antagonism. Use Caution/Monitor.
mecasermin
Monitor Closely (1)mecasermin increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Additive hypoglycemic effects.
meclofenamate
Monitor Closely (1)meclofenamate increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
mefenamic acid
Monitor Closely (1)mefenamic acid increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
meloxicam
Monitor Closely (1)meloxicam increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
mesalamine
Minor (1)mesalamine increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
mesterolone
Minor (1)mesterolone increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
methyclothiazide
Minor (1)methyclothiazide decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose.
methyl aminolevulinate
Serious - Use Alternative (1)glipizide, methyl aminolevulinate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Each drug may increase the photosensitizing effect of the other.
methylprednisolone
Minor (1)methylprednisolone decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown.
methyltestosterone
Minor (1)methyltestosterone increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
metolazone
Minor (1)metolazone decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose.
metreleptin
Monitor Closely (1)glipizide, metreleptin. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of metreleptin with insulin and/or insulin secretagogues (eg, sulfonylureas, meglitinide derivatives) may increase risk for hypoglycemia; may require lower dose of insulin or insulin secretagogue.
miconazole vaginal
Monitor Closely (1)miconazole vaginal increases levels of glipizide by decreasing metabolism. Use Caution/Monitor.
mipomersen
Monitor Closely (1)mipomersen, glipizide. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Both drugs have potential to increase hepatic enzymes; monitor LFTs.
moexipril
Monitor Closely (1)moexipril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor.
moxifloxacin
Monitor Closely (1)moxifloxacin increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely.
nabumetone
Monitor Closely (1)nabumetone increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
nadolol
Monitor Closely (1)nadolol decreases effects of glipizide by pharmacodynamic antagonism. Use Caution/Monitor. Non selective beta blockers may also mask the symptoms of hypoglycemia.
naproxen
Monitor Closely (1)naproxen increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
nelfinavir
Monitor Closely (1)nelfinavir decreases effects of glipizide by Other (see comment). Use Caution/Monitor. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. .
nettle
Minor (1)nettle increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
nitazoxanide
Monitor Closely (1)nitazoxanide, glipizide. Either increases levels of the other by Mechanism: plasma protein binding competition. Use Caution/Monitor.
nitisinone
Monitor Closely (1)nitisinone will increase the level or effect of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Nitisinone inhibits CYP2C9. Caution if CYP2C9 substrate coadministered, particularly those with a narrow therapeutic index.
nizatidine
Minor (1)nizatidine will increase the level or effect of glipizide by increasing gastric pH. Applies only to oral form of both agents. Minor/Significance Unknown.
nortriptyline
Minor (1)nortriptyline increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
ofloxacin
Monitor Closely (1)ofloxacin increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely.Minor (1)ofloxacin, glipizide. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Potential dysglycemia.
olanzapine
Monitor Closely (1)olanzapine, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
omeprazole
Minor (1)omeprazole will increase the level or effect of glipizide by affecting hepatic enzyme CYP2C19 metabolism. Minor/Significance Unknown.
opuntia ficus indica
Monitor Closely (1)opuntia ficus indica increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor.
orlistat
Minor (1)orlistat increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
ospemifene
Monitor Closely (1)glipizide, ospemifene. Either increases levels of the other by plasma protein binding competition. Modify Therapy/Monitor Closely.
oxandrolone
Minor (1)oxandrolone increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
oxaprozin
Monitor Closely (1)oxaprozin increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
oxymetholone
Minor (1)oxymetholone increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
paliperidone
Monitor Closely (1)paliperidone, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
parecoxib
Monitor Closely (1)parecoxib increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
peginterferon alfa 2b
Monitor Closely (1)peginterferon alfa 2b decreases levels of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. When patients are administered peginterferon alpha-2b with CYP2C9 substrates, the therapeutic effect of these drugs may be altered. .
pegvisomant
Minor (1)pegvisomant increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
perindopril
Monitor Closely (1)perindopril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor.
phenelzine
Monitor Closely (1)phenelzine increases effects of glipizide by unknown mechanism. Use Caution/Monitor.
pindolol
Monitor Closely (1)pindolol decreases effects of glipizide by pharmacodynamic antagonism. Use Caution/Monitor. Non selective beta blockers may also mask the symptoms of hypoglycemia.
piroxicam
Monitor Closely (1)piroxicam increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
posaconazole
Monitor Closely (1)posaconazole increases levels of glipizide by decreasing metabolism. Use Caution/Monitor.
potassium acid phosphate
Minor (1)potassium acid phosphate increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.
potassium chloride
Minor (1)potassium chloride increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.
potassium citrate
Minor (1)potassium citrate increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.
prednisolone
Minor (1)prednisolone decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown.
prednisone
Minor (1)prednisone decreases effects of glipizide by pharmacodynamic antagonism. Minor/Significance Unknown.
probenecid
Monitor Closely (1)probenecid increases levels of glipizide by unspecified interaction mechanism. Use Caution/Monitor. Risk of hypoglycemia.
propranolol
Monitor Closely (1)propranolol decreases effects of glipizide by pharmacodynamic antagonism. Use Caution/Monitor. Non selective beta blockers may also mask the symptoms of hypoglycemia.
protriptyline
Minor (1)protriptyline increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
quetiapine
Monitor Closely (1)quetiapine, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
quinapril
Monitor Closely (1)quinapril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor.
ramipril
Monitor Closely (1)ramipril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor.
rasagiline
Monitor Closely (1)rasagiline increases effects of glipizide by unknown mechanism. Use Caution/Monitor.
rifabutin
Monitor Closely (1)rifabutin decreases levels of glipizide by increasing metabolism. Use Caution/Monitor.
rifampin
Monitor Closely (1)rifampin decreases levels of glipizide by increasing metabolism. Use Caution/Monitor.
rifapentine
Monitor Closely (1)rifapentine decreases levels of glipizide by increasing metabolism. Use Caution/Monitor.
risperidone
Monitor Closely (1)risperidone, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
ritonavir
Monitor Closely (1)ritonavir, glipizide. Other (see comment). Use Caution/Monitor. Comment: Ritonavir may increase or decrease levels of glipizide. Reports of hyperglycemia due to insulin resistance with protease inhibitors. .
rucaparib
Monitor Closely (1)rucaparib will increase the level or effect of glipizide by affecting hepatic enzyme CYP2C9/10 metabolism. Modify Therapy/Monitor Closely. Adjust dosage of CYP2C9 substrates, if clinically indicated.
sage
Minor (1)sage increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
salicylates (non-asa)
Monitor Closely (1)salicylates (non-asa) increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.Minor (1)salicylates (non-asa) increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
salsalate
Monitor Closely (1)salsalate increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.Minor (1)salsalate increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
saquinavir
Monitor Closely (1)saquinavir decreases effects of glipizide by Other (see comment). Use Caution/Monitor. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. .
selegiline
Monitor Closely (1)selegiline increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Serum glucose should be monitored closely when MAOIs are added to any regimen containing antidiabetic medications. Hypoglycemic effects may be increased.
selegiline transdermal
Monitor Closely (1)selegiline transdermal increases effects of glipizide by unknown mechanism. Use Caution/Monitor.
semaglutide
Monitor Closely (1)semaglutide, glipizide. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of insulin secretagogues with GLP-1 agonists may increase hypoglycemia risk. Lowering the insulin secretagogue dose may reduce hypoglycemia risk. .
shark cartilage
Monitor Closely (1)shark cartilage increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor. Theoretical interaction.
sitagliptin
Minor (1)sitagliptin, glipizide. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Risk of hypoglycemia with combination is unknown.
sodium bicarbonate
Monitor Closely (1)sodium bicarbonate will increase the level or effect of glipizide by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.
sodium citrate/citric acid
Monitor Closely (1)sodium citrate/citric acid will increase the level or effect of glipizide by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor.
somapacitan
Monitor Closely (1)somapacitan decreases effects of glipizide by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Growth hormone products may decrease insulin sensitivity, particularly at higher doses. Antidiabetic agents may require dose adjustment after initiating somapacitan. .
stevia
Minor (1)stevia increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
sulfadiazine
Monitor Closely (1)sulfadiazine increases levels of glipizide by plasma protein binding competition. Use Caution/Monitor.
sulfamethoxazole
Monitor Closely (1)sulfamethoxazole increases levels of glipizide by plasma protein binding competition. Use Caution/Monitor.
sulfamethoxypyridazine
Monitor Closely (1)sulfamethoxypyridazine increases effects of glipizide by unspecified interaction mechanism. Use Caution/Monitor. Risk of hypoglycemia.
sulfasalazine
Monitor Closely (1)sulfasalazine increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.Minor (1)sulfasalazine increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
sulfisoxazole
Monitor Closely (1)sulfisoxazole increases levels of glipizide by plasma protein binding competition. Use Caution/Monitor.
sulindac
Monitor Closely (1)sulindac increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
tacrolimus
Minor (1)glipizide increases levels of tacrolimus by unknown mechanism. Minor/Significance Unknown.
testosterone
Minor (1)testosterone increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
testosterone buccal system
Minor (1)testosterone buccal system increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
testosterone topical
Minor (1)testosterone topical increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
timolol
Monitor Closely (1)timolol decreases effects of glipizide by pharmacodynamic antagonism. Use Caution/Monitor. Non selective beta blockers may also mask the symptoms of hypoglycemia.
tipranavir
Monitor Closely (1)tipranavir decreases effects of glipizide by Other (see comment). Use Caution/Monitor. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. .
tolfenamic acid
Monitor Closely (1)tolfenamic acid increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
tolmetin
Monitor Closely (1)tolmetin increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
tongkat ali
Minor (1)tongkat ali increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Risk of hypoglycemia.
trandolapril
Monitor Closely (1)trandolapril increases effects of glipizide by pharmacodynamic synergism. Use Caution/Monitor.
tranylcypromine
Monitor Closely (1)tranylcypromine increases effects of glipizide by unknown mechanism. Use Caution/Monitor.
trazodone
Minor (1)trazodone increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
triamcinolone acetonide injectable suspension
Monitor Closely (1)triamcinolone acetonide injectable suspension decreases effects of glipizide by pharmacodynamic antagonism. Use Caution/Monitor. Corticosteroids may diminish hypoglycemic effect of antidiabetic agents. Monitor blood glucose levels carefully.
trimagnesium citrate anhydrous
Monitor Closely (1)trimagnesium citrate anhydrous increases levels of glipizide by enhancing GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
trimipramine
Minor (1)trimipramine increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
vanadium
Minor (1)vanadium increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
voriconazole
Monitor Closely (1)voriconazole increases levels of glipizide by decreasing metabolism. Use Caution/Monitor.
willow bark
Minor (1)willow bark increases effects of glipizide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.
xipamide
Monitor Closely (1)xipamide decreases levels of glipizide by increasing renal clearance. Use Caution/Monitor.
ziprasidone
Monitor Closely (1)ziprasidone, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.

Tongkat Ali Raise Testosterone

Source: https://reference.medscape.com/drug/glucotrol-glipizide-342708

Tongkat Ali Raise Testosterone

Tongkat Ali Raise Testosterone

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